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The rate of permeation determined by efflux index method is usually described by efflux clearance ( Cl out ), which represents the net passage out of the brain and includes passive and active BBB transport as well as metabolism in the brain and elimination to the CSF by bulk flow (91)

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(2019) 'Mild depletion of vitamin B2, B6 and B12 superimposed on mild folate depletion: Effects on DNA methylation, uracil incorporation and gene expression in the mouse colon', *Scientific Reports*, 9, p

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