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Cisplatin-Induced Nephrotoxicity Cisplatin is a chemotherapy drug that treats cancer by entering the tumor cells, releasing chloride ions, and becoming hydrated to crosslink with DNA and form DNA adducts to inhibit tumor cell replication [97,98]

This effect may result from T-cell hyporesponsiveness induced by continued ROS exposure, which was induced by imbalance between ROS generation and scavenging through inhibition of antioxidant activity of Gpx1

10f), confirming the strong therapeutic effect of NP4

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