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Nature 607 , 169175 (2022)

Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Lebers disease A current infection If youre taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections

Pineal melatonin production is not inducible

The oral form has limited bioavailability (about 10%), necessitating higher doses for efficacy

Patients taking Mounjaro alongside metformin may continue metformin throughout the perioperative period unless contraindicated by acute kidney injury, dehydration, or the use of iodinated contrast media