Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]
Dont underestimate the impact that an extra few minutes spent setting expectations, discussing likely side effects, and exploring patients concerns could have on a patients whole treatment journey and weight loss outcomes, de Vere Hunt said
The rate-limiting substrate for glutathione production appears to be cysteine, hence why N-acteylcysteine has such a multitude of health benefits in clinical practice and research
In practical portfolio terms, Novo is doing what the market rewards: prove the maximal efficacy franchise first in the route with the highest probability of success, then decide whether oral conversion is worth the additional complexity
Also, some research suggests that it crosses the blood-brain barrier more easily