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Smoking is associated with elevated low-density lipoprotein cholesterol, decreased high-density lipoprotein cholesterol, increased blood catecholamine levels, increased fibrinogen levels, and impaired vascular endothelial function [36,37,38,39,40,41,42,43,44,45,46,47,48]

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In conclusion, HD illustrates the devastating consequences of single-gene mutations triggering a cascade of pathological events

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In addition, putative plant Srx proteins capable of reducing the sulfinic acid moiety through an unusual ATP-dependent mechanism as a repair enzyme 26 showed significant identities to their orthologs from yeast and humans and exhibited conserved signature sequences and residues essential for catalysis 27