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Figure 6 While the consumption of anthocyanin-rich foods, notably blueberries and apples/pears, was related to a decreased risk of T2DM in US men and women, no significant relationships were reported between total flavonoid intake and other flavonoid subclasses and T2DM risk (159)

Wei and colleagues (Wei et al., 2022) recently discovered that GLP-1 receptor activation inhibits this signaling pathway by modulating ROCK activity, leading to a reduction in the phosphorylation of MLC, which stabilizes the endothelial cell cytoskeleton and tight junctions by upregulating the expression of tight junction proteins such as Occludin and ZO-1

Proc Soc Exp Biol Med

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Mark Greenwald, Professor and Director of the Substance Addiction Research Division at Wayne State University and lead author of the study