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10.1038/jes.2015.9 60 WilkeB
Endogenous antioxidants help maintain oxidative status by delaying, inhibiting, or preventing oxidation by scavenging free radicals [2,3] and include the enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase and the non-enzymatic antioxidants such as glutathione, thioredoxin, and peroxiredoxins (Fig
As a long-acting peptide analog, Cagrilintide represents a research subject in the broader field of peptide stability engineering specifically the use of fatty acid acylation strategies to extend peptide half-life and enzymatic resistance compared to native peptide sequences
In contrast, serum levels of L-carnitine precursors, L-lysine, and TML were higher in SLC25A45 KO than in control mice, which is in agreement with the results in cultured cells that SLC25A45 is required for the conversion from TML to -BB and L-carnitine
