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Consequently, the buildup of A, which initiates well in advance of the manifestation of symptoms, is viewed as an indicator of aging and metabolic challenges in the brain rather than the root cause ( 5.5 The bidirectional cascade: crosstalk model There has been much discussion and modification of a model that describes how AD biomarkers grow in connection to one another as well as to the beginning and progression of clinical symptoms ( 6 Neuroinflammation and oxidative stress in bioenergetics failure 6.1 Microglial activation and metabolic rewiring Microglia, the indigenous immune cells of the central nervous system, are part of the myeloid lineage and play a crucial role in protecting the brain

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Furthermore, during a stroke or heart attack episode, when the clogged artery is unblocked to save the patient, a sudden flow of oxygen (reperfusion) causes significant damage of the tissue via the oxidative stress process

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Murgia, V