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The chronic activation of the HPA axis due to stress can lead to elevated levels of cortisol, a hormone known to have neurotoxic effects (Mbiydzenyuy and Qulu 2024)

A comprehensive review by Pickart, Vasquez-Soltero, and Margolina (2015), documented GHK-Cus ability to reset gene expression patterns in aged or damaged tissue toward a more regenerative state, affecting over 4,000 human genes

These effects mirror what has been seen with GLP-1 therapies but are often less intense when appropriate titration protocols are followed