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In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases ( 6 Discussion T2DM is a chronic disease characterized by hyperglycemia, which eventually leads to microvascular damage and macrovascular events, as well as complications related to peripheral vascular diseases

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[1] [2] While no dose adjustment is required for renal impairment, patients with kidney issues should be monitored for potential dehydration and kidney injury, especially if experiencing severe gastrointestinal adverse reactions

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