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In a glycemic control trial evaluating a dose comparable to the 9 mg dose and the 25 mg semaglutide tablet doses in patients with T2D, 1.3% and 1.9% of patients in the 9 mg and 25 mg semaglutide group, respectively, reported moderate-severe non-proliferative diabetic retinopathy events, and 0% and 0.4% reported proliferative retinopathy events, respectively

This approach leverages both GLP-1 receptor activation and glucose-dependent insulinotropic peptide (GIP) signalingtwo distinct endocrine pathwayswithout the cardiovascular and gastrointestinal risks of adding a sympathomimetic like phentermine

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This interaction prevents excessive autophagy from causing cell damage and further coordinates metabolic processes when the body is under stress