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The competitive map is widening, too, as the Novo Nordisk and Eli Lilly duopoly meets oral small molecules, monthly dosing, Eli Lillys retatrutide, a triple hormone receptor agonist, has demonstrated an average weight loss of 28.3% over 80 weeks on the highest dose in Phase 3 trials

[9] This weight reduction can further improve insulin sensitivity and restore menstrual regularity in many women with PCOS

28 By contrast, lifestyle interventions, including dietary modification, increased physical activity, and behavioral therapy, remain the cornerstone of first-line treatment

People who expect immediate dramatic results are more likely to feel disappointed and conclude the medication is not working, even when early physiological changes are occurring