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Pinch a fold of skin at the injection site with your non-dominant hand Hold the syringe at a 90-degree angle to the skin surface Insert the needle fully into the pinched skin fold in one smooth motion Release the skin pinch Push the plunger slowly and steadily until all medication is delivered Wait 5 to 10 seconds before removing the needle (this prevents medication from leaking back out) Remove the needle and apply gentle pressure with a clean cotton ball or gauze if needed Dispose of the syringe in a sharps container immediately Do not rub the injection site

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Avoid injecting into the same area repeatedly

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Although the absorption of drugs in the colon varies with the undigested materials, bacteria, and variable water content, GI transit still plays a key role in the absorption of drugs