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Metformin is usually chosen first because it is affordable, well tolerated long term, and effective for the majority of people newly diagnosed with type 2 diabetes

In rodents GLP-1 increases HR through a CNS pathway

In vitro studies using HGL5 cells showed melatonin reduced oxidative stress markers, improved mitochondrial function, restored expression of glycolysis and TCA cycle-related genes and modulated cuproptosis and ferroptosis-related gene expression

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However, its important to note that this not a request for a medical background