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The clinical implication of that -arrestin-sparing profile is still under investigation, but NIH-funded research published in Nature in May 2026 found that small-molecule GLP-1 drugs access reward circuits deep within the brain circuits involved in hedonic, pleasure-driven feeding through pathways that the larger peptide molecules do not reach, suggesting the two drug classes may suppress appetite through partially distinct neural mechanisms

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Better blood pressure management 41% of patients in the 8 mg groups and 30% in the 12 mg group were able to stop taking at least one antihypertensive medication after 48 weeks on retatrutide