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GPR43 activation by SCFAs reduces intracellular ATP depletion and reactive oxygen species (ROS) production, which are critical for NLRP3 assembly (132, 133)

Additionally, the mean population PK/PD parameters describing the longitudinal change in the UPDRS motor score as a function of apomorphine exposure estimated in the reference publications are summarized in Table 2 [18, 19]

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