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"Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine , 2022;387:205-216

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279,280 One study found that GLP-1R is expressed in human hepatocytes obtained from liver biopsies, and treatment with GLP-1 analogues enhanced insulin sensitivity and fatty-acid catabolism, suggesting that these analogues could improve hepatic insulin resistance in patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

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