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1 Introduction Patients with schizophrenia are characterized by modest to severe impairments in verbal learning, working memory, executive function and processing speed ( Carnitine, biosynthesized from an amino acid, is present in nearly all cells of the body ( In vivo , carnitine can be transferred with the acyl group by carnitine palmitoyltransferase 1 to produce acylcarnitine ( Antipsychotics are the first-line treatment for patients with schizophrenia and there is evidence that olanzapine (OLA) improves cognitive function in patients with schizophrenia ( Moreover, abnormal L-carnitine levels may be associated with certain mental illnesses, including schizophrenia and depression ( We hypothesized that abnormal levels of L-carnitine metabolites are associated with cognitive impairments and that changes in them after OLA monotherapy are associated with cognitive improvement in FES patients

Ruiz, L

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The precise cause is multifactorial

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