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While constantly high in MOD, BMI increased towards diagnosis in SAID and SIRD with the biggest difference 1-6 years before DM (Figure)

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Mice Kat6a heterozygous mice ( Kat6a +/ [Voss et al, 2009]) were maintained on a C57BL/6 background

Febuxostat can be used in patients with renal dysfunction as this is not a significant route of elimination