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Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

PubMed Ng, F.M., Sun, J., Sharma, L., Libinaki, R., Jiang, W.J., & Gianello, R

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But, knowing the specific interactions and talking to your doctor is always best

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