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Initially, 23 L of 0.9% isotonic saline or balanced crystalloid solution (lactated Ringers solution) should be administered over 1 to 3 hours in order to restore tissue perfusion and maintain adequate urine output

The stepwise titration schedule minimizes gastrointestinal side effects such as nausea and vomiting, which are most common during dose escalation

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GPR40, the other long chain FFA receptor, is also highly expressed and the most enriched GPCR in L-cells [266,293]