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If metformin has been controlling your blood sugar effectively, stopping it may reverse those gains unless tirzepatide alone proves sufficient for your glucose targets

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That deficit is a controlled metabolic stress

Kyeremanteng says.But managing your fluid and electrolyte balance while taking a GLP-1 RA is not a one-size-fits-all approach.The specific mechanisms by which GLP-1 RAs could impact electrolyte balance will differ depending on the individual and may include direct effects, such as altering insulin levels and influencing sodium handling by the kidneys, or indirect effects, such as decreased food, fluid, and electrolyte intake, or gastrointestinal side effects like nausea and vomiting, Dr

Dehydration can follow poor intake and may stress kidneys