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In combination with glimepiride, with or without metformin, the overall incidence of clinical adverse reactions with Januvia was higher than with placebo, in part related to a higher incidence of hypoglycemia (see Table 1)

Regulation of renal function by the gastrointestinal tract: potential role of gut-derived peptides and hormones

10.1073/pnas.2022790118 Proc Natl Acad Sci USA

(2022) demonstrated that exosomes pretreated with baicalin prevent the formation of ROS and lipid peroxide-induced ferroptosis by triggering the Keap1-Nrf2 pathway via p62 and dramatically alleviating LPS/D-GaIN-induced liver injury

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