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Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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In addition, Sema has been confirmed to have an ameliorative effect on disturbed lipid and glucose metabolism in obesity syndrome and T2DM 18,19

Stress uses up the bodys supply of vitamin B, further exacerbating symptoms