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According to FDA prescribing information, these include: Nausea (occurring in 1544% of patients depending on formulation and dose) Vomiting (524% of patients) Diarrhea (830% of patients) Abdominal pain (511% of patients) Constipation (324% of patients) These gastrointestinal symptoms typically emerge during dose escalation and often diminish over time as physiological tolerance develops

Both media were supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 2 mM glutamine (25030081), all from ThermoFisher Scientific, plus 100 units/mL penicillin (Laboratorios ERN.S.A., Madrid, Spain

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All procedures were in accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals and approved by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee (IACUC#3551)

Journal of Clinical Oncology 42(3_suppl):199, 2024