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While NADPH is essential to regenerate most key antioxidant molecules, it also plays an important role in generating ROS through the action of NADPH oxidases (NOX)

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23 In the situation of a vertebral fracture (injury type A2) but intact disc/endplate complex and in the presence of sufficient bone quality, the involved trauma energy can by assumed to be much higher than in the aforementioned twin study from Hancock and Batti