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Originally developed for type 2 diabetes, Semaglutide works by mimicking the effects of the natural hormone GLP-1

Recent research surprisingly demonstrated that serotonin-secreting enterochromaffin cells were the major chemical sensors for vagal afferent neurons in the proximal duodenum, whereas Glp1r -expressing ND neurons predominantly innervated muscle layers of the stomach and responded to stretch rather than to chemical stimuli entering the duodenum 46

I think i need to test for this.I have had my intestines taken out,depression.epilepsy.fibro,migranes,had a stroke at 50,and lost my mom at age 62 to a heart attack

Starting low and titrating gradually (0.25 mg to 0.5 mg over several weeks) allows your body to acclimate

Updated July 22, 2026 Mounjaro vs Ozempic: Which Is Better for Weight Loss and Diabetes