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Richards J, Bang N, Ratliff EL, et al

"History of growth hormone therapy"

Lo, and Michael J

These symptoms typically occur during treatment initiation or dose escalation and often improve over time, though they can be severe enough to necessitate discontinuation in some patients

community and clinical sources describe dermatological monitoring for these changes, especially with long-term use Injection site darkening localized hyperpigmentation Mood changes irritability reported by some during loading Managing nausea: community sources commonly describe beginning at 100-250 mcg, injecting before bed on an empty stomach, using anti-nausea medication (ondansetron) when needed, and escalating the dose gradually