However, they work through different receptor systems and have different drug profiles
The animal studies utilized male diet-induced obese (DIO) mice to test various GLP-1 treatments, including semaglutide and tirzepatide

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Post-Exertional Malaise (PEM) and Crashes: PEM occurs when damaged mitochondria cannot meet the energy demands of even minor physical or cognitive exertion, forcing the body into a toxic, anaerobic state
As a result, the individual will gain weight if they return to their regular eating habits