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Heppner et al., 2015

But a follow-up 2021 study, known as STEP 4, showed that within 48 weeks of no longer taking semaglutide, participants regained approximately two-thirds of their prior weight loss, while those who remained on GLP-1 drug therapy continued to lose weight

Semaglutide GLP-1 is now recommended by the FDA for chronic weight management in patients with a BMI greater than 30 kg/m2 or 27 kg/m2 but having at least one obesity-related comorbidity

Research suggests that the dual receptor action may make this class of drugs more effective at promoting weight loss than other GLP-1s