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The realistic timeline, based on the current trial schedule: Q2-Q3 2026 TRIUMPH-1 and TRIUMPH-2 primary readouts

Meaningful weight loss typically occurs gradually, and the most significant results often take time to develop

For context, GLP-1s are only FDA-approved for people whose BMI is at least 30, or for people with a BMI of 27 and who have a weight-related health condition

41 The significant reduction in urinary oxalate excretion after weight loss through GLP-based therapies could possibly be attributed to decreased intake of oxalate and oxalate precursors or to reduced hepatic oxalate synthesis

The GIP component enhances insulin secretion and contributes to adipose tissue metabolism