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Our interpretation of the biological relevance of our effect size estimates is further supported by several laboratory studies showing that when protein carbonyls accumulate, they tend to aggregate and can lead to cell death, tissue injury and development of disorders 33,34

In the yeast Saccharomyces cerevisiae, the opposite effect is observed: under low zinc conditions, an elevated glutathione concentration is found. So right there, in the abstract, they say that mammals and yeast behave in an opposite fashion when it comes to zinc and glutathione

Our findings are consistent with these previous reports, as we observed attenuation of A plaques and tau pathology in CR-fed 3xTg mice

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This hypothesis was also validated in a lipopolysaccharide (LPS)-induced systemic inflammation rat model (28)