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They only become a problem when theyre swollen and inflamed, which causes them to become painful for the patient

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Refrigeration at 28C slows both processes dramatically

Kim et al., 2009)

DCCT sub-analyses established that glycemic variability (not just HbA1c) predicts diabetic complication risk, making pramlintide's variability-reducing effects potentially more clinically important than the modest HbA1c change alone