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Research interest focuses on signalling coordination, receptor-specific activation, and pathway timing rather than prolonged or isolated pathway engagement

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Long-term study results are currently limited, but the following must be considered for shaping the clinical algorithm in GLP-1 RA prescribing: proper indication, the characteristics of the prescribed drug, the patient's psychiatric and somatic history, sociodemographic factors, patient expectations, and especially monitoring of response to rapid weight loss (Figure 1)