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Delay muscle fatigue

63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidationreduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2 (eIF2) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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Other experimental work shows that different IGF-1 isoforms may produce different muscle responses, which supports the idea that splice-variant context matters [11]

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