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The most common ones are usually mild and improve over time: Nausea (especially when starting) Diarrhea or constipation Decreased appetite Fatigue during adjustment period Stomach discomfort Serious But Rare Side Effects More serious side effects are uncommon but require medical attention: Severe allergic reactions Pancreatitis (inflammation of the pancreas) Gallbladder problems Low blood sugar (if combined with diabetes medications) Kidney problems Sleep-Related Considerations Some people report temporary sleep changes when starting GLP-1 medications: Initial insomnia or restlessness (usually improves) Changes in dream patterns Temporary fatigue as body adjusts Mood changes that can affect sleep Most sleep-related side effects resolve within a few weeks as your body adapts to the medication

This is also called a partial.thickness tear

Additionally, GLP-1 agonists significantly reduce food intake

A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses