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Lillys oral GLP-1 molecule, Orforglipron, is also under FDA review

muciniphila might similarly regulate LPS-induced inflammation by upregulating Gene Activating transcription factor 3 ( Atf3 ), a transcription factor that negatively regulates proinflammatory cytokine transcription, when the latter is induced by TLR4 activation [103]

Aug 2018;49(4):319-327