Cells co-expressing OsDHAR and ScSRX rapidly recovered under H 2 O 2 -induced oxidative stress compared to cells expressing OsDHAR (WT), OsDHAR (C20A) and OsDHAR (C20A) + ScSRX (Fig
BPC 157 1992
In the mammalian circadian clock, CRY proteins essentially replace tim and partner with PER proteins to form repressor complexes that drive rhythmic gene expression (Yagita et al., 2002

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Therefore, exogenous expression in aged astrocytes of a cytoplasmically targeted PC gene could possibly decrease cellular senescence and inflammation from the senescence-associated secretory phenotype (SASP) to delay brain aging