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This epidemiological evidence, combined with the direct presence of GLP-1 receptors in the brain, has prompted researchers to explore whether these medications might offer cognitive benefits independent of their metabolic effects

This superficial location makes them vulnerable to repetitive strain but also makes them accessible for local treatment approaches

HepaRG (a cell line isolated from a cholangiocarcinoma, that can be differentiated in vitro to adult hepatic cells) and HepG2 (a differentiated cell line exhibiting epithelial-like morphology, isolated from a hepatocellular carcinoma) are widely available and have been used extensively in liver metabolism and hepatotoxicity studies

When to act: Rhabdomyolysis is rare but serious