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Its inability to move the needle on pain was a bit surprising given study evidence it can do so in peripheral neuropathy

doi:10.1017/S1461145711000617, PMID: 21733244 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT (2011) Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

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Standard dosing: 250-500mcg once or twice daily represents the most common protocol

Warmly Dr Jill I appreciate the response, and perhaps you are the exception to my view of functional/integrative/alternative medicine doctors, but even with a fairly straightforward situation (homozygous a1298c but none of the other problematic methylation SNPs one reads about), I cant seem to get a coherent recommendation