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De Araujo is finding that adverse reactions might be caused by how the drug differs from the naturally occurring peptide hormone: The hormone acts mostly locally and degrades quickly, while the medicine works mainly on the brain and is designed to stick around in the body

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A Quick Reference for Non-Specialist Clinicians LIKELY APPROPRIATE BMI 35, no eating disorder history Type 2 diabetes + overweight Cardiovascular risk reduction Metabolic syndrome REQUIRES EATING DISORDER SPECIALIST CONSULT FIRST Binge eating disorder Any prior mental health diagnosis History of disordered eating Adolescents / young adults DO NOT PRESCRIBE / HIGH RISK Active anorexia nervosa Active restrictive eating disorder History of MTC or MEN2 Active pancreatitis A Note on Autonomy, Judgment, and What We Owe Our Patients The following reflects my personal opinion and clinical perspective

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Dietary fibre from whole foods should remain the foundation of fibre intake whenever possible