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J Biomed Sci (2014) 21:39.10.1186/1423-0127-21-39 39 EckhertCDHsuMHPangN

Am Heart J 2011;162:818.e6825.e6 [DOI] [PubMed] 29.Mullard A

18 The SYNERGY-NASH (A Study of Tirzepatide [LY3298176] in Participants With Nonalcoholic Steatohepatitis) trial, 19 a phase 2b dose-finding study, randomized 190 patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis to receive weekly injections of the GLP-1 and GIP dual agonist tirzepatide 5 mg, 10 mg, or 15 mg or placebo for 52 weeks

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When researchers compared them indirectly, oral semaglutide outperformed orforglipron by about 3 percentage points on weight loss, and patients were roughly 4 times less likely to discontinue due to side effects