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Chemical Synthesis, Developability, and Native Chemical Ligation From a purely chemical synthesis perspective, the immense size and structural complexity of the retatrutide molecule present extreme developability challenges

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Most patients regain approximately 50% of lost weight within one year of stopping tirzepatide, indicating that the chronic condition of weight dysregulation typically requires ongoing treatment

Funding This work was supported by National Institutes of Health Grants R01-DK-114663, P01-HL-62222 and endowed McIntyre Professorship to K.P