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La coactivacin de receptores GIP y GLP-1 tiene el potencial de intensificar estos efectos mediante mecanismos metablicos complementarios: mientras GLP-1 favorece la saciedad, la ralentizacin gstrica y la mejora de la secrecin de insulina en respuesta a nutrimentos, el GIP puede potenciar la accin teraputica al influir en la secrecin de insulina dependiente de glucosa y en la regulacin del tejido adiposo

PlexusDx patients may benefit from the Precision Peptide Genetic Test ($99 add-on after first month), which analyzes genetic variants in appetite-regulation pathways including GLP1R rs6923761 and MC4R rs17782313

Its plasma concentration decreases with age: approximately 200 ng/ml at age 20 versus 80 ng/ml at age 60, correlating with the decline in regenerative capacity