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Ensure consistent fluid intake throughout the day, particularly if experiencing gastrointestinal side effects

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These include the POMC-derived peptides released by neighbouring keratinocytes and the neuropeptide calcitonin gene-related peptide, substance P, and neuropeptide Y released from intramucosal free nerve endings, which are in close contact with melanocytes in the basal cell layer of the epithelium

Jackson Laboratory, Bar Harbor, Maine) were housed in standard cages under controlled lighting (12h light/12h dark cycle) and temperature 22C with access to food and water ad libitum