Key Contraindications (Both) Active malignancy or recent cancer history, pregnancy, breastfeeding, uncontrolled diabetes, severe pituitary disease
Interestingly, this has not discouraged multiple research groups testing cysteine prodrugs, such as N-acetylcysteine (NAC), as supplements to increase glutathione (GSH) levels
However, even with a balanced diet, many people may not get enough to meet their bodys needs, especially if they exercise frequently or follow a plant-based diet
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In emergency treatment of acquired methemoglobinemia (typically using IV MB), the dose is weight-based, usually 1-2 mg/kg intravenously, which for an average adult (70 kg) is on the order of 70-140 mg administered once and can be repeated once if needed