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Therefore, coordinately regulating the expression and activity of lipid metabolism enzymes like ACSL4 and LPCAT3 is considered an important intervention strategy from the perspective of reducing the source of ferroptosis substrates (Habaxi et al., 2024)

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Subcellular distribution of Prussian blue nanozymes dictates enzymatic activity and macrophage polarization for effective colitis therapy

Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

thus, the levels of pyruvate carboxylase can greatly affect the sensitivity of tumor cells to inhibition of glutamine metabolism 111