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"Target-organ toxicity: liver and kidney"

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It has a complex etiology and is linked to a variety of genetic and environmental risk factors, including smoking, light, and diet [19, 20]

A pivotal study (Yano et al., Cell, 2015) showed that the microbiota influence the serotonergic system through an entire constellation of metabolites many produced by spore-forming Clostridia, the same group known for butyrate and broad gut-supportive functions