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In clinical pharmacology trials with semaglutide 1 mg once weekly injection, semaglutide did not affect the absorption of orally administered medications

therefore, these findings reflect a robust therapeutic signal rather than incidental findings (type I error)

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They may include: They may include: Nausea Vomiting Diarrhea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Abdominal pain Decreased appetite Indigestion Redness at injection site Redness at injection site Most symptoms improve over time

Statistically, these changes were distinct when compared with placebo