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31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026

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Amide peak intensities in the 2D 1 H- 15 N heteronuclear single quantum coherence (HSQC) spectrum of this 15 N-isotope labeled and MTSL-conjugated S tail were measured in the oxidized (I ox ) and reduced (I red ) states (Fig